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Trường DCGiá trị Ngôn ngữ
dc.contributor.authorDuong, Thuc-Huy-
dc.contributor.authorDevi, Asshaima Paramita-
dc.contributor.authorTran, Nguyen-Minh-An-
dc.contributor.authorPhan, Hoang-Vinh-Truong-
dc.contributor.authorHuynh, Ngoc-Vinh-
dc.contributor.authorSichaemg, Jirapast-
dc.contributor.authorTrand, Hoai-Duc-
dc.contributor.authorAlam, Mahboob-
dc.contributor.authorNguyen, Thi- Phuong-
dc.contributor.authorNguyen, Huu-Hung-
dc.contributor.authorChavasiric, Warinthorn-
dc.contributor.authorNguyen, Tien-Cong-
dc.date.accessioned2021-06-10T13:40:02Z-
dc.date.available2021-06-10T13:40:02Z-
dc.date.issued2020-
dc.identifier.issn0960-​894X-
dc.identifier.otherBBKH2493-
dc.identifier.urihttp://thuvienso.vanlanguni.edu.vn/handle/Vanlang_TV/31184-
dc.description16p.; 1 MBvi
dc.description.abstractA series of novel N-substituted hydrazide derivatives were synthesized by reacting atranorin, a compound with a natural depside structure (1), with a range of hydrazines. The natural product and 12 new analogues (2-13) were investigated for inhibition of α-glucosidase. The N-substituted hydrazide derivatives showed more potent inhibition than the original. The experimental results were confirmed by docking analysis. This study suggests that these compounds are promising molecules for diabetes therapy. Molecular dynamics simulations were carried out with compound 2 demonstrating the best docking model using Gromac during simulation up to 20 ns to explore the stability of the complex ligand-protein. Furthermore, the activity of all synthetic compounds 2-13 against a normal cell line HEK293, used for assessing their cytotoxicity, was evaluatedvi
dc.language.isoenvi
dc.publisherBioorganic & Medicinal Chemistry Lettersvi
dc.subjectParmotrema tsavoensevi
dc.subjectatranorinvi
dc.subjectN-substituted hydrazide derivativesvi
dc.subjectα-glucosidasevi
dc.subjectcytotoxicityvi
dc.subjectinhibitionvi
dc.titleSynthesis, α-glucosidase Inhibition, And Molecular Docking Studies Of Novel Nsubstituted Hydrazide Derivatives Of Atranorin As Antidiabetic Agentsvi
dc.typeArticlevi
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