A Q&A N-1 Bioreactor Perfusion Capability

Abstract

Samsung Biologics successfully performed N-1 (3,000-L) perfusion with ATF to supply the 15,000-L commercial production process in the Plant 3 facility at its manufacturing site in Songdo, South Korea. [...]the cell line must exhibit sufficient robustness with regard to shear stress or sensitivity to the micro-environment. Kenneth Green, PhD Cell Culture Manufacturing Operations Samsung Biologics "The ATF system differs from other perfusion technologies with the application of hollow fiber filters and alternating flow as opposed to Tangential Flow Filtration or centrifugation."