The Road to Real-Time Release At-line NIR Testing

Abstract

Several tests can be performed on exactly the same sample during the manufacturing process, such as measurement of weight and content needed for a content uniformity assay. [...]a system is a good start for the definition of the real-time release (RTR) strategy. Advantages of spectroscopic techniques Spectroscopic techniques, such as near infrared (NIR) spectroscopy, are noninvasive, non-destructive, and allow fast quality control investigations on higher amounts of samples during the complete manufacturing process. [...]NIR exhibits great potential as a PAT tool for control of the critical parameters during production and better process understanding. Additionally, unwanted scatter light, which escapes from the sides of a sample (tablet), also has a high influence on the measurement precision and should be avoided. [...]new challenges for an automated at-line PAT solution are precise and repetitive positioning and avoiding scattered light when measuring during the process.